RPS4Y1

Across TCGA pan-cancer cohorts, RPS4Y1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RPS4Y1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RPS4Y1 RNA is repressed in tumor relative to normal tissue. In most cancer types RPS4Y1 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and STAD are the cancer types where RPS4Y1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS4Y1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.500	.003	6	view →
HNSC	Male	III,IV	−1.753	.001	4	view →
STAD	Male	All	−1.386	<.001	4	view →
KIRP	Male	II,III,IV	−2.634	<.001	3	view →
CHOL	Male	All	+1.849	<.001	3	view →
COAD	Female	All	+0.813	.008	2	view →
LUSC	Male	All	−0.844	.001	1	view →
LUAD	Male	All	−0.609	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RPS4Y1–KICH

Open the KICH breakdown →