Across TCGA pan-cancer cohorts, RPS3AP48 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPS3AP48’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where RPS3AP48 RNA is repressed in tumor relative to normal tissue. In most cancer types RPS3AP48 is over-expressed in tumor, although a few such as UCEC and READ show the opposite, repressed pattern.
UCEC and READ are the cancer types where RPS3AP48 tumor–normal differential expression is most reproducible.