RPS15A

Across TCGA patient cohorts, RPS15A mutation is significantly associated with the RNA expression of many other genes, with 154 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS15A-associated genes across cancer lineages are LARP1, WHAMM, and PAXIP1. Each is linked with RPS15A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS15A-to-partner and partner-to-RPS15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP1 grouped by RPS15A-low versus RPS15A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS15A→partner) and Y-score (partner→RPS15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LARP1 →	+0.585	+3.191	.007	.009	3	1
UCEC	WHAMM →	+0.930	+3.201	<.001	.009	3	1
UCEC	PAXIP1 →	+0.673	+3.256	.001	.008	3	1
UCEC	CCNF →	+0.835	+3.191	.004	.009	3	1
UCEC	RNF34 →	+0.542	+3.223	.001	.009	3	1
UCEC	PDP2 →	+0.631	+3.234	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 154 associations by consensus.

LARP1 by RPS15A expression — UCEC

Explore this box plot interactively →