RPS15A

Across TCGA patient cohorts, RPS15A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS15A-associated genes across cancer lineages are FoxM1, INPP4B, and Myosin-IIa. Each is linked with RPS15A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS15A-to-partner and partner-to-RPS15A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RPS15A-low versus RPS15A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS15A→partner) and Y-score (partner→RPS15A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.304	+3.169	.032	.020	3	1
UCEC	INPP4B →	-0.384	-3.000	.030	.036	3	1
UCEC	Myosin-IIa →	+0.232	+3.177	.022	.010	3	1
UCEC	BRCA2 →	-0.150	-3.162	.031	.019	3	1
UCEC	Claudin-7 →	-0.583	-3.169	.035	.020	3	1
UCEC	VHL →	-1.329	-3.169	<.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FoxM1 by RPS15A expression — UCEC

Explore this box plot interactively →