RPS10-NUDT3

Across TCGA pan-cancer cohorts, RPS10-NUDT3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RPS10-NUDT3 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RPS10-NUDT3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPS10-NUDT3 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

KIRP, ACC, and SCLC are the cancer types where RPS10-NUDT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.818	0.940	<.001	99	view →
ACC	DFS	Quartile	All	0.199	0.740	<.001	76	view →
SCLC	OS	Tertile	All	0.515	0.841	<.001	58	view →
BRCA	DFS	Median	IV	0.401	0.913	<.001	40	view →
LGG	DFS	Median	All	0.804	0.654	<.001	36	view →
UCS	OS	Median	II,III,IV	0.776	0.426	.008	34	view →
SARC	OS	Median	All	0.666	0.819	<.001	31	view →
THYM	OS	Median	II,III,IV	0.964	0.597	.001	27	view →
UCEC	DFS	Quartile	All	0.764	0.875	.001	26	view →
GBM	OS	Quartile	All	0.549	0.324	.007	26	view →
PRAD	DFS	Tertile	All	0.833	0.934	.002	18	view →
OV	DFS	Tertile	IV	0.477	0.194	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RPS10-NUDT3–KIRP (DFS)

Open the KIRP breakdown →