RPS10-NUDT3

Across TCGA pan-cancer cohorts, RPS10-NUDT3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RPS10-NUDT3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPS10-NUDT3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS10-NUDT3 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where RPS10-NUDT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS10-NUDT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.134	.012	6	view →
LUSC	Male	All	+0.259	<.001	5	view →
LUAD	All	All	+0.111	.001	5	view →
BRCA	All	All	+0.094	<.001	4	view →
COAD	All	All	+0.122	.016	3	view →
CHOL	All	All	+0.265	.002	2	view →
THCA	All	All	+0.049	.003	2	view →
KIRC	All	All	+0.061	.038	1	view →
LIHC	Male	III,IV	−0.046	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RPS10-NUDT3–HNSC

Open the HNSC breakdown →