RPRD2

Across TCGA patient cohorts, RPRD2 mutation is significantly associated with the RNA expression of many other genes, with 5,734 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPRD2-associated genes across cancer lineages are SEC13, SAP30, and CNTROB. Each is linked with RPRD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPRD2-to-partner and partner-to-RPRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by RPRD2-low versus RPRD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRD2→partner) and Y-score (partner→RPRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.323	+2.447	<.001	.001	3	3
UCEC	SAP30 →	+0.596	+2.072	<.001	<.001	3	3
UCEC	CNTROB →	+0.266	+1.719	.009	.006	3	3
UCEC	INHBC →	+0.160	+2.032	.001	.002	3	3
UCEC	TOP3A →	+0.617	+2.632	<.001	<.001	3	3
UCEC	UFD1 →	+0.411	+3.424	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,734 associations by consensus.

SEC13 by RPRD2 expression — UCEC

Explore this box plot interactively →