RPRD1B

Across TCGA patient cohorts, RPRD1B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPRD1B-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ERK2. Each is linked with RPRD1B in more than 1 cancer types. Because this analysis shows association rather than direction, both RPRD1B-to-partner and partner-to-RPRD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RPRD1B-low versus RPRD1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRD1B→partner) and Y-score (partner→RPRD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.209	-1.906	.038	.016	3	1
UCEC	eIF4E →	+0.198	+2.415	.019	.003	3	1
UCEC	ERK2 →	+0.247	+2.415	.001	.003	3	1
UCEC	ACC1 →	+0.289	+1.906	.048	.016	3	1
UCEC	MSH2 →	-0.226	-1.848	.014	.049	3	1
UCEC	mTOR_pS2448 →	-0.197	-3.446	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by RPRD1B expression — UCEC

Explore this box plot interactively →