RPRD1B

Across TCGA pan-cancer cohorts, RPRD1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RPRD1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPRD1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPRD1B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where RPRD1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPRD1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.825	<.001	12	view →
COAD	Male	II,III,IV	+0.905	<.001	10	view →
THCA	Male	III,IV	−0.965	<.001	9	view →
STAD	All	II,III,IV	+0.964	<.001	7	view →
BRCA	All	III,IV	+0.551	<.001	6	view →
LUAD	Male	All	+0.366	<.001	6	view →
LUSC	Male	II,III,IV	+0.734	<.001	5	view →
KICH	All	All	−0.654	<.001	5	view →
ESCA	All	II,III,IV	+1.014	.004	4	view →
CHOL	All	All	+0.954	<.001	2	view →
UCEC	All	All	−0.816	<.001	2	view →
READ	All	All	+0.624	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RPRD1B–HNSC

Open the HNSC breakdown →