RPP40

Across TCGA cell cohorts, RPP40 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,842 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RPP40-associated GO terms across cancer lineages are tRNA 5'-leader removal, RNA 5'-end processing, and tRNA 5'-end processing. Each is linked with RPP40 in more than 16 cancer types. Because this analysis shows association rather than direction, both RPP40-to-partner and partner-to-RPP40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA 5'-leader removal grouped by RPP40-low versus RPP40-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP40→partner) and Y-score (partner→RPP40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	tRNA 5'-leader removal →	+0.132	+1.572	.004	.001	3	17
PANCREAS	RNA 5'-end processing →	+0.092	+1.336	<.001	<.001	3	17
OESOPHAGUS	tRNA 5'-end processing →	+0.148	+1.686	.002	.001	3	17
BLOOD_Myeloma	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.149	+1.059	<.001	<.001	3	16
BLOOD_Myeloma	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.099	+0.913	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.151	+1.140	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,842 associations by consensus.

tRNA 5'-leader removal by RPP40 expression — OESOPHAGUS

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