RPP38

Across TCGA pan-cancer cohorts, RPP38 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RPP38 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RPP38 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPP38 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where RPP38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.466	0.811	.006	13	view →
LSCC	DFS	Tertile	II,III,IV	0.845	0.486	.018	12	view →
UCEC	DFS	Tertile	III,IV	1.000	0.407	.016	8	view →
LUAD	DFS	Tertile	All	0.689	1.000	.011	5	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.916	.042	2	view →
CCRCC	OS	Median	III,IV	0.842	1.000	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RPP38–PDAC (DFS)

Open the PDAC breakdown →