RPP38

Across TCGA pan-cancer cohorts, RPP38 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RPP38’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPP38 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPP38 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, LIHC, and STAD are the cancer types where RPP38 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPP38 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.398	<.001	11	view →
LIHC	Male	II,III,IV	+1.148	<.001	9	view →
STAD	All	II,III,IV	+0.870	<.001	9	view →
KICH	Female	All	−1.025	<.001	8	view →
HNSC	Male	III,IV	+0.588	<.001	8	view →
COAD	Male	II,III,IV	+0.443	<.001	8	view →
KIRP	All	II,III,IV	+0.360	.018	6	view →
LUSC	All	All	+0.286	<.001	6	view →
CHOL	Male	All	+1.815	<.001	5	view →
LUAD	Male	All	+0.332	.002	5	view →
BRCA	All	All	+0.166	.003	4	view →
READ	All	III,IV	+0.710	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RPP38–KIRC

Open the KIRC breakdown →