RPP38-DT

Across TCGA pan-cancer cohorts, RPP38-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPP38-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RPP38-DT RNA is repressed in tumor relative to normal tissue. In most cancer types RPP38-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where RPP38-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPP38-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.443	<.001	10	view →
THCA	Female	All	−0.508	<.001	7	view →
KIRC	Male	II,III,IV	−0.112	<.001	7	view →
COAD	All	II,III,IV	+0.205	.001	6	view →
BRCA	Female	All	−0.199	<.001	6	view →
LIHC	All	All	+0.116	<.001	5	view →
STAD	Male	All	+0.218	<.001	4	view →
LUAD	Female	II,III,IV	−0.269	.005	3	view →
LUAD	All	IV	+0.490	.013	2	view →
CHOL	All	All	+0.453	<.001	2	view →
KIRP	All	IV	+0.272	.025	2	view →
PRAD	All	All	+0.200	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPP38-DT–KICH

Open the KICH breakdown →