RPL6P27

Across TCGA pan-cancer cohorts, RPL6P27 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RPL6P27’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL6P27 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL6P27 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where RPL6P27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL6P27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.881	<.001	12	view →
LIHC	All	II,III,IV	+1.197	<.001	9	view →
KIRP	All	II,III,IV	+0.533	.003	8	view →
BRCA	Female	All	−0.435	<.001	4	view →
LUSC	All	All	+0.315	.012	3	view →
CHOL	Male	All	+2.206	<.001	2	view →
UCEC	All	All	−0.805	.034	2	view →
PRAD	All	All	+0.353	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RPL6P27–KIRC

Open the KIRC breakdown →