Across TCGA pan-cancer cohorts, RPL5P27 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RPL5P27’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RPL5P27 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL5P27 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, COAD, and LUAD are the cancer types where RPL5P27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL5P27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.067	.003	2	view →
COAD	Female	All	+0.128	.035	1	view →
LUAD	Male	II,III,IV	+0.096	.029	1	view →
KIRP	Male	II,III,IV	+0.034	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RPL5P27 RNA expression & survival · all RPL5P27 data types