Q-omics provides the consensus-scored RPL5P27 profile across patient tissues and cancer cell-line models. RPL5P27 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, RPL5P27 is differentially expressed in 4, with the highest sampling consensus in THCA. Additionally, RPL5P27 RNA expression shows 11,885 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight LUAD, THCA, and GBM as cancer lineages where RPL5P27 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RPL5P27 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RPL5P27 survival associations across molecular data types. RPL5P27 RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RPL5P27 RNA expression–survival associations across cancer types. High RPL5P27 expression shows unfavorable associations in LUAD and MESO, but favorable associations in BLCA, READ, LUSC and SKCM. The LUAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .013). Together, the overview and detailed table identify LUAD as the clearest survival context for RPL5P27 RNA expression.
This table summarizes RPL5P27 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for RPL5P27. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RPL5P27 shows lower tumor expression in THCA and higher tumor expression in COAD, LUAD and KIRP. The THCA box plot shows higher RPL5P27 RNA expression in normal versus tumor tissue (log2 FC = −0.067, t-test p = .003).
This table shows molecular features associated with RPL5P27 in patient tissues and cancer cell lines. In patient samples, RPL5P27 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
