RPL5P16

Across TCGA pan-cancer cohorts, RPL5P16 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated RPL5P16 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPL5P16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPL5P16 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LGG show a favorable association.

HNSC, KIRC, and THCA are the cancer types where RPL5P16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.429	0.612	.002	117	view →
KIRC	OS	Tertile	II,III,IV	0.560	0.804	<.001	114	view →
THCA	OS	Tertile	All	0.832	0.995	<.001	57	view →
GBM	DFS	Tertile	All	0.097	0.262	.005	36	view →
ESCA	DFS	Tertile	IV	0.826	0.284	.034	36	view →
MESO	DFS	Tertile	II,III,IV	0.216	0.422	.027	27	view →
UCEC	OS	Tertile	All	0.825	0.930	.014	24	view →
KIRP	OS	Tertile	All	0.321	0.735	.003	24	view →
SKCM	OS	Tertile	IV	0.179	0.755	<.001	18	view →
LIHC	OS	Tertile	II,III,IV	0.350	0.705	.003	12	view →
SARC	DFS	Tertile	All	0.187	0.551	.005	9	view →
OV	OS	Tertile	All	0.719	0.850	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

RPL5P16–HNSC (DFS)

Open the HNSC breakdown →