RPL3L

Across TCGA cell cohorts, RPL3L mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPL3L-associated genes across cancer lineages are FAM47B, SPAG11A, and APELA. Each is linked with RPL3L in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL3L-to-partner and partner-to-RPL3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47B grouped by RPL3L-low versus RPL3L-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL3L→partner) and Y-score (partner→RPL3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM47B →	+0.013	+5.228	<.001	.005	3	1
SKIN	SPAG11A →	+0.036	+4.022	<.001	.006	3	1
SKIN	APELA →	+0.070	+3.877	<.001	.003	3	1
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	1
LARGE_INTESTINE	MCHR2 →	+0.021	+3.099	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FAM47B by RPL3L expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →