RPL39L

Across TCGA cell cohorts, RPL39L RNA expression is significantly associated with the go_rna of many other GO terms, with 2,594 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RPL39L-associated GO terms across cancer lineages are Negative regulation of double-strand break repair, DNA replication initiation, and Regulation of attachment of spindle microtubules to kinetochore. Each is linked with RPL39L in more than 8 cancer types. Because this analysis shows association rather than direction, both RPL39L-to-partner and partner-to-RPL39L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of double-strand break repair grouped by RPL39L-low versus RPL39L-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL39L→partner) and Y-score (partner→RPL39L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of double-strand break repair →	+0.079	+2.011	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.158	+2.470	<.001	.001	3	8
BLOOD_Lymphoma	Regulation of attachment of spindle microtubules to kinetochore →	+0.109	+1.544	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.063	+1.826	.001	.002	3	8
BONE	Nuclear DNA replication →	+0.182	+2.309	.004	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Interstrand cross-link repair →	+0.057	+1.747	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,594 associations by consensus.

Negative regulation of double-strand break repair by RPL39L expression — BONE

Explore this box plot interactively →