RPL39L

Across TCGA pan-cancer cohorts, RPL39L RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RPL39L’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RPL39L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL39L is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

LUAD, LUSC, and HNSC are the cancer types where RPL39L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL39L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+2.346	<.001	9	view →
LUSC	Female	All	+3.520	<.001	8	view →
HNSC	Male	IV	+2.710	<.001	8	view →
BRCA	All	III,IV	+1.222	<.001	6	view →
LIHC	All	All	+1.039	<.001	6	view →
STAD	All	All	+0.835	.004	6	view →
CHOL	Male	All	+3.663	<.001	5	view →
UCEC	All	All	+0.961	.001	4	view →
KIRC	Male	All	+0.503	.001	4	view →
KICH	All	All	−0.841	.002	3	view →
BLCA	Male	IV	−2.205	.001	2	view →
READ	Male	All	+1.266	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RPL39L–LUAD

Open the LUAD breakdown →