RPL34-DT

Across TCGA pan-cancer cohorts, RPL34-DT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RPL34-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RPL34-DT RNA is repressed in tumor relative to normal tissue. In most cancer types RPL34-DT is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where RPL34-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL34-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−0.450	<.001	11	view →
KIRC	Male	II,III,IV	−0.387	<.001	11	view →
KICH	Male	All	−0.572	<.001	7	view →
KIRP	Male	All	−0.288	<.001	7	view →
COAD	Female	All	−0.071	.001	4	view →
UCEC	All	All	−0.089	.007	2	view →
LUSC	All	II,III,IV	−0.079	.005	2	view →
ESCA	All	All	−0.250	.024	1	view →
STAD	All	IV	−0.143	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RPL34-DT–THCA

Open the THCA breakdown →