RPL28

Across TCGA patient cohorts, RPL28 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL28-associated genes across cancer lineages are IGFBP2, MEK1, and p21. Each is linked with RPL28 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL28-to-partner and partner-to-RPL28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by RPL28-low versus RPL28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL28→partner) and Y-score (partner→RPL28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.651	-1.700	.018	.044	3	1
UCEC	MEK1 →	+0.439	+3.459	.004	.005	3	1
UCEC	p21 →	+0.168	+2.906	.039	.001	3	1
UCEC	p62 Lck ligand →	+0.330	+2.179	.016	.034	3	1
UCEC	Annexin-1 →	+0.440	+2.189	.049	.034	3	1
UCEC	TIGAR →	+0.163	+2.248	.011	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IGFBP2 by RPL28 expression — UCEC

Explore this box plot interactively →