RPL28

Across TCGA pan-cancer cohorts, RPL28 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RPL28’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL28 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL28 is over-expressed in tumor.

KIRC, KIRP, and COAD are the cancer types where RPL28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.993	<.001	12	view →
KIRP	All	III,IV	+1.232	<.001	11	view →
COAD	Female	All	+1.385	<.001	10	view →
LIHC	Female	II,III,IV	+1.420	<.001	9	view →
THCA	All	II,III,IV	+0.706	<.001	8	view →
CHOL	Male	All	+2.175	<.001	5	view →
LUSC	Male	All	+0.468	<.001	4	view →
STAD	All	All	+0.436	.010	4	view →
BRCA	All	All	+0.242	.016	4	view →
READ	All	All	+0.866	<.001	3	view →
UCEC	All	All	+0.577	.003	2	view →
PRAD	All	All	+0.447	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RPL28–KIRC

Open the KIRC breakdown →