RPL27AP4

Across TCGA pan-cancer cohorts, RPL27AP4 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated RPL27AP4 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RPL27AP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RPL27AP4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LIHC show a favorable association.

ACC, THCA, and PAAD are the cancer types where RPL27AP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.324	0.834	<.001	180	view →
THCA	OS	Tertile	II,III,IV	0.925	0.981	<.001	72	view →
PAAD	OS	Tertile	II,III,IV	0.252	0.561	.004	36	view →
COAD	OS	Tertile	IV	0.047	0.679	<.001	36	view →
LUAD	OS	Tertile	III,IV	0.318	0.671	.040	36	view →
ESCA	OS	Tertile	All	0.598	0.895	.043	9	view →
LUSC	DFS	Tertile	II,III,IV	0.664	0.335	.041	6	view →
UCEC	OS	Tertile	All	0.764	0.880	.022	6	view →
LGG	OS	Tertile	All	0.715	0.892	.039	3	view →
LIHC	DFS	Tertile	II,III,IV	1.000	0.393	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RPL27AP4–ACC (OS)

Open the ACC breakdown →