RPL27A

Across TCGA pan-cancer cohorts, RPL27A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RPL27A data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPL27A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPL27A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, GBM, and PDAC are the cancer types where RPL27A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.670	0.890	.006	16	view →
GBM	DFS	Median	All	0.254	0.487	<.001	13	view →
PDAC	OS	Quartile	III,IV	0.368	0.868	.020	10	view →
LUAD	OS	Median	II,III,IV	0.449	0.893	.023	9	view →
LSCC	OS	Median	All	1.000	0.925	.014	6	view →
CCRCC	DFS	Tertile	III,IV	0.359	0.621	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RPL27A–HNSC (DFS)

Open the HNSC breakdown →