RPL27A

Across TCGA pan-cancer cohorts, RPL27A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RPL27A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL27A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL27A is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRC, LIHC, and COAD are the cancer types where RPL27A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL27A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.965	<.001	12	view →
LIHC	Female	II,III,IV	+1.109	<.001	9	view →
COAD	Female	II,III,IV	+0.685	<.001	8	view →
KIRP	All	All	+0.500	<.001	8	view →
BRCA	Female	II,III,IV	−0.334	<.001	4	view →
CHOL	Male	All	+1.821	<.001	3	view →
PRAD	All	All	+0.213	.043	2	view →
KICH	Female	All	−0.659	.017	1	view →
LUAD	All	All	+0.212	.040	1	view →
LUSC	All	All	+0.183	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RPL27A–KIRC

Open the KIRC breakdown →