RPL23AP86

Across TCGA pan-cancer cohorts, RPL23AP86 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RPL23AP86’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPL23AP86 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL23AP86 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, LUSC, and BLCA are the cancer types where RPL23AP86 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL23AP86 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.167	<.001	9	view →
LUSC	Male	All	+0.147	.001	5	view →
BLCA	All	III,IV	+0.206	.002	4	view →
COAD	Male	II,III,IV	+0.167	.001	4	view →
BRCA	Female	II,III,IV	+0.104	.004	4	view →
LIHC	All	III,IV	+0.063	.017	4	view →
CHOL	Female	All	+0.320	<.001	2	view →
KIRP	Female	II,III,IV	+0.310	<.001	2	view →
KICH	All	All	−0.229	.014	2	view →
READ	Male	All	+0.223	.026	2	view →
KIRC	All	II,III,IV	−0.098	.039	2	view →
LUAD	Male	All	+0.198	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RPL23AP86–HNSC

Open the HNSC breakdown →