RPL23AP81

Across TCGA pan-cancer cohorts, RPL23AP81 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RPL23AP81 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher RPL23AP81 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPL23AP81 expression acts as an unfavorable survival marker, although some lineages such as UCS and PAAD show a favorable association.

LGG, KICH, and KIRP are the cancer types where RPL23AP81 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.633	0.835	<.001	54	view →
KICH	OS	Median	All	0.856	0.982	.010	34	view →
KIRP	DFS	Quartile	All	0.549	0.820	.001	31	view →
UCS	OS	Tertile	IV	0.844	0.178	.024	30	view →
MESO	OS	Quartile	All	0.256	0.475	.013	29	view →
PAAD	OS	Quartile	All	0.633	0.321	.001	25	view →
UVM	OS	Median	All	0.777	1.000	.013	18	view →
READ	DFS	Median	IV	0.289	0.777	<.001	15	view →
ACC	DFS	Median	All	0.562	0.893	.010	15	view →
LUAD	OS	Tertile	All	0.443	0.306	.029	9	view →
HNSC	OS	Tertile	II,III,IV	0.560	0.414	.020	9	view →
CESC	DFS	Tertile	III,IV	0.308	0.697	.030	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RPL23AP81–LGG (DFS)

Open the LGG breakdown →