RPL23AP81

Across TCGA pan-cancer cohorts, RPL23AP81 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RPL23AP81’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RPL23AP81 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL23AP81 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

COAD, LIHC, and UCEC are the cancer types where RPL23AP81 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL23AP81 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	IV	+0.720	.001	9	view →
LIHC	All	All	+0.103	<.001	8	view →
UCEC	All	All	+0.476	.001	6	view →
THCA	Female	All	−0.394	<.001	6	view →
CHOL	All	All	+0.376	.003	3	view →
LUAD	Female	II,III,IV	−0.373	.008	3	view →
KICH	All	All	−0.295	.002	2	view →
KIRP	Male	All	−0.256	.007	2	view →
LUSC	All	II,III,IV	−0.270	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RPL23AP81–COAD

Open the COAD breakdown →