RPL22P21

Across TCGA patient cohorts, RPL22P21 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,189 significant associations in total. STAD shows the largest number of these associations.

The most reproducible RPL22P21-associated GO terms across cancer lineages are Negative regulation of telomere maintenance via telomere lengthening, Lipoprotein biosynthetic process, and Negative regulation of gene expression, epigenetic. Each is linked with RPL22P21 in more than 15 cancer types. Because this analysis shows association rather than direction, both RPL22P21-to-partner and partner-to-RPL22P21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of telomere maintenance via telomere lengthening grouped by RPL22P21-low versus RPL22P21-high in COAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL22P21→partner) and Y-score (partner→RPL22P21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Negative regulation of telomere maintenance via telomere lengthening →	+0.042	+0.105	<.001	.002	3	16
STAD	Lipoprotein biosynthetic process →	+0.053	+0.331	<.001	<.001	3	15
ESCA	Negative regulation of gene expression, epigenetic →	+0.061	+0.331	.004	<.001	2	16
ESCA	Regulation of mRNA splicing, via spliceosome →	+0.071	+0.240	.004	.004	2	16
ESCA	Translational elongation →	+0.058	+0.241	.004	.002	2	16
COAD	Negative regulation of DNA metabolic process →	+0.044	+0.119	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,189 associations by consensus.

Negative regulation of telomere maintenance via telomere lengthening by RPL22P21 expression — COAD

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