RPL22P21

Across TCGA pan-cancer cohorts, RPL22P21 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated RPL22P21 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RPL22P21 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RPL22P21 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

BLCA, SKCM, and BRCA are the cancer types where RPL22P21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.849	0.332	.011	45	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	18	view →
BRCA	OS	Tertile	III,IV	0.989	0.888	.021	18	view →
LIHC	DFS	Tertile	III,IV	0.076	0.333	.003	18	view →
THCA	OS	Tertile	II,III,IV	0.508	0.913	.013	15	view →
LGG	DFS	Tertile	All	0.305	0.424	.030	12	view →
READ	OS	Tertile	II,III,IV	0.187	0.653	.030	9	view →
LUAD	OS	Tertile	All	0.933	0.818	.027	9	view →
ACC	OS	Tertile	III,IV	0.189	0.764	.004	9	view →
LUSC	DFS	Tertile	II,III,IV	0.181	0.554	.037	6	view →
LAML	DFS	Median	All	0.582	0.323	.016	6	view →
STAD	DFS	Median	III,IV	0.273	0.577	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

RPL22P21–BLCA (OS)

Open the BLCA breakdown →