RPL21

Across TCGA patient cohorts, RPL21 mutation is significantly associated with the RNA expression of many other genes, with 157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL21-associated genes across cancer lineages are RNU1-15P, LIMS4, and RNU6ATAC21P. Each is linked with RPL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL21-to-partner and partner-to-RPL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-15P grouped by RPL21-low versus RPL21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL21→partner) and Y-score (partner→RPL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-15P →	+0.259	+7.816	<.001	.008	3	2
UCEC	LIMS4 →	+0.045	+2.515	<.001	.005	3	2
BLCA	RNU6ATAC21P →	+0.248	+7.640	<.001	.009	3	1
BLCA	RNU6-193P →	+0.288	+7.640	<.001	.009	3	1
BLCA	USP17L3 →	+0.034	+7.640	<.001	.009	3	1
BLCA	MTCO2P3 →	+0.129	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 157 associations by consensus.

RNU1-15P by RPL21 expression — SKCM

Explore this box plot interactively →