RPL21

Across TCGA pan-cancer cohorts, RPL21 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPL21’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RPL21 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL21 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, KIRC, and LUAD are the cancer types where RPL21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.577	<.001	10	view →
KIRC	Female	All	+0.556	<.001	10	view →
LUAD	All	III,IV	−0.901	<.001	9	view →
LIHC	All	All	+0.515	<.001	7	view →
LUSC	All	All	−0.453	<.001	7	view →
UCEC	All	All	−1.193	<.001	6	view →
BRCA	Female	II,III,IV	−0.715	<.001	6	view →
CHOL	Male	All	+1.733	<.001	5	view →
KICH	Female	II,III,IV	−1.719	<.001	5	view →
COAD	All	II,III,IV	+0.410	.011	4	view →
THCA	All	All	−0.353	.002	3	view →
KIRP	All	All	−0.358	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPL21–BLCA

Open the BLCA breakdown →