RPL21

Across TCGA patient cohorts, RPL21 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL21-associated genes across cancer lineages are Annexin-1, c-Kit, and JNK2. Each is linked with RPL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL21-to-partner and partner-to-RPL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by RPL21-low versus RPL21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL21→partner) and Y-score (partner→RPL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.689	+2.827	.012	.035	3	1
UCEC	c-Kit →	-0.268	-2.980	.028	.036	2	1
UCEC	JNK2 →	+0.216	+3.321	.038	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Annexin-1 by RPL21 expression — UCEC

Explore this box plot interactively →