RPL21

Across TCGA cell cohorts, RPL21 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,451 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RPL21-associated GO terms across cancer lineages are Negative regulation of cytoplasmic pattern recognition receptor signaling pathway, Cytokinetic process, and Endosomal transport. Each is linked with RPL21 in more than 12 cancer types. Because this analysis shows association rather than direction, both RPL21-to-partner and partner-to-RPL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway grouped by RPL21-low versus RPL21-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL21→partner) and Y-score (partner→RPL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	-0.108	-1.066	<.001	.002	3	13
LIVER	Cytokinetic process →	-0.090	-0.640	.001	.004	3	12
BONE	Endosomal transport →	-0.073	-0.996	.002	<.001	3	12
OVARY	Negative regulation of autophagy →	-0.064	-0.757	.003	.001	2	13
BLOOD_Leukemia	Macroautophagy →	-0.037	-0.509	<.001	.003	2	13
CNS	Positive regulation of axon extension →	-0.082	-0.619	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,451 associations by consensus.

Negative regulation of cytoplasmic pattern recognition receptor signaling pathway by RPL21 expression — KIDNEY

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