RPL18A

Across TCGA patient cohorts, RPL18A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL18A-associated genes across cancer lineages are FoxM1, Rab11, and Rab25. Each is linked with RPL18A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL18A-to-partner and partner-to-RPL18A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RPL18A-low versus RPL18A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL18A→partner) and Y-score (partner→RPL18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.230	+3.009	.048	.019	3	1
UCEC	Rab11 →	-0.150	-2.700	.022	.006	3	1
UCEC	Rab25 →	-0.352	-2.999	.018	.035	3	1
UCEC	S6_pS240_S244 →	+0.376	+2.000	.040	.032	3	1
UCEC	VHL →	-1.077	-3.459	<.001	.005	3	1
UCEC	Caspase-7-cleavedD198 →	+0.605	+2.827	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FoxM1 by RPL18A expression — UCEC

Explore this box plot interactively →