RPL18

Across TCGA patient cohorts, RPL18 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL18-associated genes across cancer lineages are MIR4445, RNU6-1191P, and RN7SKP112. Each is linked with RPL18 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL18-to-partner and partner-to-RPL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by RPL18-low versus RPL18-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL18→partner) and Y-score (partner→RPL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4445 →	+0.401	+7.731	<.001	.009	3	2
CESC	RNU6-1191P →	+1.260	+5.688	<.001	<.001	3	2
SKCM	RN7SKP112 →	+0.132	+3.070	.005	.004	3	2
BRCA	SNORD115-2 →	+0.412	+8.055	<.001	.007	3	1
BRCA	RNU6-849P →	+0.292	+8.055	<.001	.007	3	1
BRCA	RNU6-364P →	+0.333	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

MIR4445 by RPL18 expression — BRCA

Explore this box plot interactively →