RPL14P1

Across TCGA pan-cancer cohorts, RPL14P1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPL14P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPL14P1 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL14P1 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where RPL14P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL14P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.590	<.001	11	view →
COAD	Female	II,III,IV	+1.107	<.001	10	view →
LIHC	Male	II,III,IV	+0.980	<.001	9	view →
KIRP	Male	All	+0.518	.002	8	view →
BRCA	Female	II,III,IV	−0.390	<.001	4	view →
CHOL	All	All	+1.442	.001	2	view →
UCEC	All	All	−0.699	.007	2	view →
PRAD	All	All	+0.524	<.001	2	view →
LUSC	All	All	−0.275	.015	2	view →
KIRC	All	All	+0.272	.004	2	view →
KICH	Female	All	−0.504	.032	1	view →
THCA	Female	II,III,IV	+0.329	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPL14P1–HNSC

Open the HNSC breakdown →