Across TCGA pan-cancer cohorts, RPL12P24 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL12P24’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RPL12P24 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL12P24 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRP and KIRC are the cancer types where RPL12P24 tumor–normal differential expression is most reproducible.