Across TCGA pan-cancer cohorts, RPL12P23 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL12P23’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RPL12P23 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL12P23 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and LUAD are the cancer types where RPL12P23 tumor–normal differential expression is most reproducible.