RPL10L

Across TCGA patient cohorts, RPL10L mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL10L-associated genes across cancer lineages are ASNS, Cyclin-E1, and p38-MAPK. Each is linked with RPL10L in more than 2 cancer types. Because this analysis shows association rather than direction, both RPL10L-to-partner and partner-to-RPL10L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RPL10L-low versus RPL10L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL10L→partner) and Y-score (partner→RPL10L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.417	+1.874	.001	.049	3	3
LUSC	Cyclin-E1 →	+0.346	+2.468	.004	.011	3	2
COAD	p38-MAPK →	+0.199	+2.815	.038	.036	3	2
UCEC	Annexin-1 →	+0.502	+1.894	.008	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.764	+1.827	<.001	.015	3	2
LUSC	Fibronectin →	-0.517	-2.450	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ASNS by RPL10L expression — UCEC

Explore this box plot interactively →