Across TCGA pan-cancer cohorts, RPIAP1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPIAP1’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RPIAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPIAP1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
BLCA, KICH, and HNSC are the cancer types where RPIAP1 tumor–normal differential expression is most reproducible.