RPH3A

Across TCGA patient cohorts, RPH3A mutation is significantly associated with the RNA expression of many other genes, with 4,791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPH3A-associated genes across cancer lineages are TRAF2, MRPL11, and CIDECP1. Each is linked with RPH3A in more than 3 cancer types. Because this analysis shows association rather than direction, both RPH3A-to-partner and partner-to-RPH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAF2 grouped by RPH3A-low versus RPH3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPH3A→partner) and Y-score (partner→RPH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAF2 →	+0.324	+2.264	.003	.005	3	4
SKCM	MRPL11 →	+0.336	+2.169	<.001	.003	3	3
UCEC	CIDECP1 →	+0.387	+2.577	<.001	<.001	3	3
UCEC	SAPCD2 →	+0.630	+2.818	.001	.001	3	3
UCEC	AJM1 →	+0.438	+2.423	.003	.001	3	3
COAD	MIR599 →	+0.471	+2.887	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,791 associations by consensus.

TRAF2 by RPH3A expression — UCEC

Explore this box plot interactively →