RPH3A

Across TCGA pan-cancer cohorts, RPH3A RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RPH3A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RPH3A RNA is repressed in tumor relative to normal tissue. In most cancer types RPH3A is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LUSC are the cancer types where RPH3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPH3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.191	<.001	11	view →
LUAD	Male	All	−0.281	<.001	8	view →
LUSC	All	II,III,IV	−0.255	<.001	6	view →
KICH	Male	II,III,IV	−0.093	.001	6	view →
KIRC	Male	All	+0.081	<.001	5	view →
HNSC	All	III,IV	+0.026	.007	4	view →
READ	All	III,IV	−0.145	.019	3	view →
THCA	All	All	+0.065	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RPH3A–COAD

Open the COAD breakdown →