RPH3A

Across TCGA patient cohorts, RPH3A mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPH3A-associated genes across cancer lineages are ATM, CDK1, and SF2. Each is linked with RPH3A in more than 2 cancer types. Because this analysis shows association rather than direction, both RPH3A-to-partner and partner-to-RPH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RPH3A-low versus RPH3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPH3A→partner) and Y-score (partner→RPH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.353	-2.584	.034	.010	3	3
UCEC	CDK1 →	+0.155	+2.222	.005	.010	3	3
BLCA	SF2 →	+0.264	+3.000	.007	.036	2	3
COAD	mTOR_pS2448 →	-0.190	-3.157	.011	.018	2	3
COAD	MYH11 →	-1.202	-2.576	.027	.011	3	2
COAD	RAD51 →	+0.180	+1.882	.006	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by RPH3A expression — UCEC

Explore this box plot interactively →