RPH3A

Across TCGA cell cohorts, RPH3A mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPH3A-associated genes across cancer lineages are GPR119, GPR139, and PRAMEF10. Each is linked with RPH3A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPH3A-to-partner and partner-to-RPH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by RPH3A-low versus RPH3A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPH3A→partner) and Y-score (partner→RPH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GPR119 →	+0.022	+4.867	<.001	.009	3	2
SOFT_TISSUE	GPR139 →	+0.019	+4.369	<.001	.008	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF14 →	+0.302	+4.523	<.001	.003	3	1
LUNG_SCLC	PRAMEF15 →	+0.494	+4.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GPR119 by RPH3A expression — BLOOD_Lymphoma

Explore this box plot interactively →