RPGR

Across TCGA patient cohorts, RPGR mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPGR-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and EGFR_pY1068. Each is linked with RPGR in more than 1 cancer types. Because this analysis shows association rather than direction, both RPGR-to-partner and partner-to-RPGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by RPGR-low versus RPGR-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPGR→partner) and Y-score (partner→RPGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	4E-BP1 →	+0.655	+2.816	.002	.036	3	2
UCEC	14-3-3_beta →	-0.107	-1.986	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.208	-1.502	.006	.027	3	2
UCEC	JNK2 →	+0.226	+2.584	<.001	<.001	3	2
UCEC	PCNA →	+0.180	+1.754	.005	.001	3	2
UCEC	Rab25 →	-0.333	-1.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

4E-BP1 by RPGR expression — LUSC

Explore this box plot interactively →