RPGR

Across TCGA pan-cancer cohorts, RPGR RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RPGR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RPGR RNA is repressed in tumor relative to normal tissue. In most cancer types RPGR is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LIHC are the cancer types where RPGR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPGR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.822	<.001	10	view →
LUAD	Female	III,IV	−1.131	<.001	9	view →
LIHC	All	II,III,IV	+0.574	<.001	9	view →
COAD	All	II,III,IV	+0.537	<.001	8	view →
STAD	All	II,III,IV	+0.667	<.001	7	view →
LUSC	Female	All	−1.219	<.001	6	view →
KICH	Female	All	−0.993	<.001	6	view →
BRCA	Female	II,III,IV	−0.487	<.001	6	view →
CHOL	Male	All	+1.626	<.001	5	view →
UCEC	All	All	−0.786	.002	2	view →
ESCA	All	All	+0.684	.021	2	view →
KIRP	Male	All	−0.360	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RPGR–THCA

Open the THCA breakdown →