RPGR

Across TCGA cell cohorts, RPGR mutation is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPGR-associated genes across cancer lineages are OR7G1, TRPA1, and MED26. Each is linked with RPGR in more than 1 cancer types. Because this analysis shows association rather than direction, both RPGR-to-partner and partner-to-RPGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7G1 grouped by RPGR-low versus RPGR-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPGR→partner) and Y-score (partner→RPGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR7G1 →	+0.017	+5.266	<.001	.001	3	1
LARGE_INTESTINE	TRPA1 →	+0.562	+2.559	<.001	.007	3	1
LARGE_INTESTINE	MED26 →	+0.306	+3.067	.004	.009	3	1
LARGE_INTESTINE	CNFN →	+0.934	+3.169	.001	.006	3	1
LARGE_INTESTINE	TWNK →	+0.521	+3.364	.001	.002	3	1
LARGE_INTESTINE	SLC30A3 →	+0.861	+3.364	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

OR7G1 by RPGR expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →