RPF1

Across TCGA patient cohorts, RPF1 mutation is significantly associated with the RNA expression of many other genes, with 935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPF1-associated genes across cancer lineages are RNA5SP412, RNA5SP422, and RN7SL248P. Each is linked with RPF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPF1-to-partner and partner-to-RPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by RPF1-low versus RPF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPF1→partner) and Y-score (partner→RPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.399	+2.382	.008	<.001	3	3
UCEC	RNA5SP422 →	+0.666	+2.086	<.001	.002	3	3
UCEC	RN7SL248P →	+0.062	+3.219	<.001	.004	3	2
LUAD	RPL12P3 →	+0.271	+4.268	<.001	.008	3	2
HNSC	SSX4 →	+0.038	+6.763	<.001	<.001	3	2
UCEC	RNA5SP419 →	+0.587	+2.183	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 935 associations by consensus.

RNA5SP412 by RPF1 expression — UCEC

Explore this box plot interactively →